Synthesis of Macrolides.
K. C. Nicolaou, Tetrahedron, 1977, 33, 683.
Key Words:
TARGET SYNTHESIS/MACROLIDES
Chemical synthesis of Glycosphingolipids.
K. C. Nicolaou, Chemtracts: Organic Chemistry, 1991, 4,
181.
Key Words:
TARGET SYNTHESIS/MISCELLANEOUS
New synthetic methods and strategies and total synthesis of natural products.
K. C. Nicolaou, Aldrichimica Acta, 1993, 26, 63.
Key Words:
The battle of calicheamicin gamma1.
K. C. Nicolaou, Angew. Chem., Int. Ed. Engl., 1993, 32,
5377.
Key Words:
The total synthesis of brevetaxin B: A twelve-year odyssey in organic
synthesis.
K. C. Nicolaou, Angew. Chem., Int. Ed. Engl., 1996, 35,
589.
Key Words:
BREVETOXIN B/NATURAL PRODUCTS/TOTAL SYNTHESES/BREVETOXIN-B/RING-SYSTEM/STEREOCONTROLLED
SYNTHESIS/TETRAHYDROPYRAN SYSTEMS/EPOXIDE OPENINGS/HEMIBREVETOXIN-B/CONSTRUCTION/TECHNOLOGY/PALYTOXIN/DITHIATOPAZINE
Chemistry, biology, and medicine of the glycopeptide antibiotics.
K. C. Nicolaou, C. N. C. Boddy, S. Brase, N. Winssinger, Angew. Chem., Int.
Ed. Engl., 1999, 38, 2097.
Key Words:
biaryls/glycopeptides/mode of action/total synthesis/vancomycin/ALPHA-AMINO-ACIDS/VANCOMYCIN-RESISTANT
ENTEROCOCCI/CARBOXYLATE-BINDING POCKET/C-O-D/ALANYL-D-ALANINE/FORMAL TOTAL
SYNTHESIS/NUCLEOPHILIC AROMATIC-SUBSTITUTION/ULLMANN MACROCYCLIZATION REACTION/INHIBITING
GP120-CD4 BINDING/INTRAMOLECULAR SNAR REACTION
Does CIP nomenclature adequately handle molecules with multiple
stereoelements? A case study of vancomycin and cognates.
K. C. Nicolaou, C. N. C. Boddy, J. S. Siegel, Angew. Chem., Int. Ed. Engl., 2001,
40, 701.
Key Words:
atropisomerism; cycloisomerism; nomenclature; stereochemistry; vancomycin;
RING SKELETON; AGLYCON; STEREOISOMERISM; CHIRALITY; CONSTRUCTION; REVISION
Synthesis of novel oligosaccharides.
K. C. Nicolaou, T. J. Caulfield, R. D. Groneberg, Pure Appl. Chem., 1991,
63, 555.
Key Words:
FUNCTIONAL GROUPS/TRANSFORMATIONS/CARBOHYDRATES
Chemistry and biology of enediyne anticancer antibiotics.
K. C. Nicolaou, W.-M. Dai, Angew. Chem., Int. Ed. Engl., 1991, 30,
1387.
Key Words:
Chemistry and biology of taxol.
K. C. Nicolaou, W.-M. Dai, R. K. Guy, Angew. Chem., Int. Ed. Engl., 1994,
33, 15.
Key Words:
The conquest of taxol.
K. C. Nicolaou, R. K. Guy, Angew. Chem., Int. Ed. Engl., 1995, 34,
2079.
Key Words:
NATURAL PRODUCTS/TAXOL/TOTAL SYNTHESES/CONVERGENT STRATEGY/TAXANE/VERTICILLENE/ALKALOIDS/SYSTEM
The Wittig and related reactions in natural product synthesis.
K. C. Nicolaou, M. W. Harter, J. L. Gunzner, A. Nadin, Liebigs Ann. Chem., 1997,
1283.
Key Words:
Wittig reactions/Horner/Wadsworth-Emmons/natural products/total synthesis/STEREOCONTROLLED
TOTAL SYNTHESIS/IONOPHORE ANTIBIOTIC X-14547A/ENDIANDRIC ACID CASCADE/KEY
BUILDING-BLOCKS/AMPHOTERICIN-B/AMPHOTERONOLIDE-B/BREVETOXIN-B/ORGANIC-SYNTHESIS/GENERATION
STRATEGIES/OLEFINATION REACTION
Chemistry, Biology and Medicine of Selected Tubulin Polymerizing Agents.
K. C. Nicolaou, D. Hepworth, N. P. King, M. R. V. Finlay, Pure Appl. Chem., 1999,
71, 989.
Key Words:
Tubulin polymerizing agents Taxol Sarcodictyin
K. C. Nicolaou, N. P. King, Y. He, in Alkene Metathesis in Organic Synthesis
(Ed.: A. Furstner), Springer-Verlag Berlin, Heidelberger Platz 3/W-1000 Berlin
33/Germany, 1998, pp. 73.
Key Words:
ring-closing metathesis/epothilones/Tebbe reagent/Petasis reagent/maitotoxin
Adventures in carbohydrate chemistry: New synthetic technologies, chemical
synthesis, molecular design, and chemical biology.
K. C. Nicolaou, H. J. Mitchell, Angew. Chem., Int. Ed. Engl., 2001,
40, 1576.
Key Words:
carbohydrates; glycosidation; natural products; synthetic methods; total
synthesis; SOLID-PHASE SYNTHESIS; 16-MEMBERED-RING MACROLIDE ANTIBIOTICS; KEY
BUILDING-BLOCKS; FG RING-SYSTEM; BETA-D-GLUCOSE; TO-TAIL DIMER; BREVETOXIN-B;
GLYCOSYL FLUORIDES; AMPHOTERICIN-B; STEREOCONTROLLED SYNTHESIS
The total synthesis of Amphoteronolide B and Amphotericin B.
K. C. Nicolaou, W. W. Ogilvie, Chemtracts: Organic Chemistry, 1990,
3, 327.
Key Words:
TARGET SYNTHESIS/MACROLIDES
K. C. Nicolaou, N. A. Petasis, in Strategies and Tactics in Organic
Synthesis, Vol. 1 (Ed.: T. Lindberg), Academic Press, 1984.
Key Words:
Lipoxins and related eicosanoids: biosynthesis, biological properties, and
chemical synthesis.
K. C. Nicolaou, J. Y. Ramphal, N. A. Petasis, C. N. Serhan, Angew. Chem.,
Int. Ed. Engl., 1991, 30, 1100.
Key Words:
Recent developments in the chemistry, biology and medicine of the epothilones.
K. C. Nicolaou, A. Ritzen, K. Namoto, J. Chem. Soc., Chem. Commun., 2001,
1523.
Key Words:
MACROLACTONIZATION-BASED STRATEGY; ENANTIOSELECTIVE TOTAL SYNTHESIS;
MICROTUBULE-STABILIZING AGENTS; COMMON PHARMACOPHORE; SIDE-CHAIN;
STEREOSELECTIVE SYNTHESIS; DESOXYEPOTHILONE-B; ANTITUMOR-ACTIVITY; CHEMICAL
SYNTHESIS; NATURAL-PRODUCTS
Chemical biology of epothilones.
K. C. Nicolaou, F. Roschangar, D. Vourloumis, Angew. Chem., Int. Ed. Engl., 1998,
37, 2015.
Key Words:
antitumor agents/epothilones/natural products/structure-activity
relationships/total synthesis/RING-CLOSING METATHESIS/MICROTUBULE DYNAMIC
INSTABILITY/OLEFIN METATHESIS/NATURAL-PRODUCTS/PACLITAXEL TAXOL/SIGNAL-TRANSDUCTION/MACROLACTONIZATION
APPROACH/KINETIC STABILIZATION/ASYMMETRIC-SYNTHESIS/ORGANIC-SYNTHESIS
Molecular design, chemical synthesis, and biological action of enediynes.
K. C. Nicolaou, A. L. Smith, Acc. Chem. Res., 1992, 25,
497.
Key Words:
Progress towards the total synthesis of the ene-diyne anticancer antibiotics.
K. C. Nicolaou, A. L. Smith, Pure Appl. Chem., 1993, 65,
1271.
Key Words:
K. C. Nicolaou, A. L. Smith, in Modern Acetylene Chemistry (Eds.: P. J.
Stang, F. Diederich), V C H Verlagsgesellschaft, Weinheim, Germany, 1995,
pp. 203.
Key Words:
Synthesis of DNA-binding oligosaccharides.
K. C. Nicolaou, B. M. Smith, J. Pastor, Y. Watanabe, D. S. Weinstein, Synlett,
1997, 401.
Key Words:
oligosaccharide/DNA-binding/CALICHEAMICIN OLIGOSACCHARIDE/ANTITUMOR
ANTIBIOTICS/DUPLEX DNA/DOMAIN/CALICHEMICIN-GAMMA-1/GAMMA-1(I)/CHEMISTRY/CLEAVAGE/FAMILY
The Diels-Alder reaction in total synthesis
K. C. Nicolaou, S. A. Snyder, T. Montagnon, G. Vassilikogiannakis, Angew.
Chem., Int. Ed. Engl., 2002, 41, 1668.
Key Words:
biomimetic synthesis/cycloaddition/Diels-Alder reaction/molecular diversity/total
synthesis/FORMAL TOTAL SYNTHESIS/ENANTIOSELECTIVE TOTAL SYNTHESIS/IONOPHORE
ANTIBIOTIC X-14547A/BIOMIMETIC TOTAL SYNTHESIS/STEREOCONTROLLED TOTAL SYNTHESIS/STEREOSPECIFIC
TOTAL SYNTHESIS/ASYMMETRIC TOTAL SYNTHESIS/HYDROXY-O-QUINODIMETHANES/CP
MOLECULES CP-263,114/ENDIANDRIC ACID CASCADE
K. C. Nicolaou, E. J. Sorensen, Classics in Total Synthesis. Targets,
Strategies, Methods., VCH, Weinheim, 1996.
Key Words:
Chemistry and biology of selected natural products.
K. C. Nicolaou, E. A. Theodorakis, C. F. Claiborne, Pure Appl. Chem., 1996,
68, 2129.
Key Words:
PROTEIN-KINASE-C/BREVETOXIN-B/SQUALENE SYNTHASE/ANTITUMOR ANTIBIOTICS/ZARAGOZIC
ACIDS/TAXOL/RAPAMYCIN/INHIBITORS/BINDING/FAMILY
K. C. Nicolaou, H. Ueno, in Preparative Carbohydrate Chemistry (Ed.: S.
Hanessian), Marcel Dekker, 270 Madison Ave/New York/NY 10016, 1997, pp.
313.
Key Words:
The art and science of total synthesis at the dawn of the twenty-first
century.
K. C. Nicolaou, D. Vourloumis, N. Winssinger, P. S. Baran, Angew. Chem., Int.
Ed. Engl., 2000, 39, 45.
Key Words:
drug research/natural products/synthetic methods/total synthesis/ENANTIOSELECTIVE
TOTAL SYNTHESIS/FORMAL TOTAL SYNTHESIS/BETA-LACTAM ANTIBIOTICS/STEREOSPECIFIC
TOTAL SYNTHESIS/ASYMMETRIC TOTAL SYNTHESIS/STEREOCONTROLLED TOTAL SYNTHESIS/SPONGE
THEONELLA-SWINHOEI/DIELS-ALDER REACTION/TEMPORARY SILICON CONNECTION/MARINE
TOXIC POLYETHERS