Diastereoselective construction of small building blocks via [2+2] cycloadditions involving ketenes: A direct incorporation of alpha-, beta-, and gamma-amino acids into peptides.

C. Palomo, J. M. Aizpurua, I. Ganboa, Russian Chemical Bulletin, 1996, 45, 2463.

Key Words:



Asymmetric Synthesis of beta-Lactams by Staudinger Ketene-Imine Cycloaddition Reaction.

C. Palomo, J. M. Aizpurua, I. Ganboa, M. Oiarbide, Eur. J. Org. Chem., 1999, 3223.

Key Words:
Lactams/beta-/asymmetric synthesis Ketene-imine cycloaddition



Versatility of beta-lactams in synthesis. Studies directed toward the synthesis of complex nucleoside antibiotics and some macrocyclic peptides.

C. Palomo, J. M. Aizpurua, I. Ganboa, M. Oiarbide, Pure Appl. Chem., 2000, 72, 1763.

Key Words:
N-CARBOXY ANHYDRIDES/ALPHA-AMINO-ACIDS/CONCISE SYNTHESIS/SYNTHON METHOD/ESTERS/FRAMEWORKS/ACCESS



beta-Lactams as versatile intermediates in alpha- and beta-amino acid synthesis.

C. Palomo, J. M. Aizpurua, I. Ganboa, M. Oiarbide, Synlett, 2001, 1813.

Key Words:
beta-lactams/beta-amino acids/alpha-amino acids/peptides/N-CARBOXY ANHYDRIDES/PEPTIDYL NUCLEOSIDE ANTIBIOTICS/ASYMMETRIC-SYNTHESIS/ENANTIOSELECTIVE SYNTHESIS/SYNTHON METHOD/BUILDING-BLOCKS/ROUTE/ESTERS/COMBINATION/INHIBITORS



The aldol addition reaction: An old transformation at constant rebirth

C. Palomo, M. Oiarbide, J. M. Garcia, Chem. Eur. J., 2002, 8, 37.

Key Words:
aldol reaction/catalysts/chiral auxiliaries/practical processes/HALIDE-ALDEHYDE CYCLOCONDENSATIONS/ENANTIOMER-SELECTIVE ACTIVATION/ACYCLIC STEREOSELECTION/ASYMMETRIC CATALYSIS/ENOLATE EQUIVALENTS/CARBONYL-COMPOUNDS/ORGANIC-SYNTHESIS/TITANIUM ENOLATE/ACETATE ENOLATE/SYN ALDOLS