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Horner-Emmons Synthesis with Minimal Purification Using ROMPGEL:  A Novel High-Loading Matrix for Supported Reagents

Anthony G. M. Barrett, Susan M. Cramp, Richard S. Roberts and Frederic J. Zecri

*Department of Chemistry, Imperial College of Science, Technology and Medicine, London SW7 2AY, United Kingdom, Email: agm.barrettimperial.ac.uk

A. G. M. Barrett, S. M. Cramp, R. S. Roberts, F. J. Zecri, Org. Lett., 1999, 1, 579-582.

DOI: 10.1021/ol990694k (free Supporting Information)


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Abstract

Two high-loading Horner-Emmons ring-opening metathesis polymers can be used for the synthesis of α,β-unsaturated ethyl esters (E:Z > 99:1) and α,β-unsaturated nitriles (E:Z > 70:30) in excellent yields and purities from aldehydes with minimal purification.

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ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis

E. Arstad, A. G. M. Barrett, B. T. Hopkins, J. Koebberling, Org. Lett., 2002, 4, 1975-1977.


Key Words

Wittig-Horner Reaction, unsaturated esters


ID: J54-Y1999