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Convenient Catalytic Free Radical Reductions of Alkyl Halides Using an Organotin Reagent on Non-Cross-Linked Polystyrene Support

Eric J. Enholm and James P. Schulte

*Department of Chemistry, University of Florida, Gainesville, Florida 32611, Email: enholmchem.ufl.edu

E. J. Enholm, J. P. Schulte, Org. Lett., 1999, 1, 1275-1277.

DOI: 10.1021/ol990945p (free Supporting Information)



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Abstract

A highly efficient and catalytic organotin reagent on soluble support has been developed for free radical reactions. A variety of alkyl halides (1, 2, 3, aryl) underwent radical reductions in good isolated yields using only 0.01-0.2 equiv of the polymer catalyst.

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Key Words

dehalogenations, organotin hydrides, sodium borohydride


ID: J54-Y1999