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Cesium Hydroxide Promoted Chemoselective N-Alkylation for the Generally Efficient Synthesis of Secondary Amines

Ralph N. Salvatore, Advait S. Nagle, Shaun E. Schmidt and Kyung Woon Jung

*Department of Chemistry (CHE 305), University of South Florida, 4202 E. Fowler Avenue, Tampa, Florida 33620-5250, Email:

R. N. Salvatore, A. S. Nagle, S. E. Schmidt, K. W. Jung, Org. Lett., 1999, 1, 1893-1896.

DOI: 10.1021/ol9910417


Cesium hydroxide promotes a selective N-monoalkylation of primary amines to prepare various secondary amines efficiently. This methodology is highly chemoselective, favoring mono-N-alkylation over dialkylation.

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Key Words

secondary amines

ID: J54-Y1999