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Direct Synthesis of β-Aminoketones from Amides via Novel Sequential Nucleophilic Substitution/Michael Reaction

Arthur Gomtsyan*

*Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, Illinois 60064

A. Gomtsyan, Org. Lett., 2000, 2, 11-13.

DOI: 10.1021/ol9911122

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A sequential nucleophilic substitution at the carbonyl group of amides by vinylmagnesium bromide followed by Michael reaction after quench by water provides β-aminoketones.

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Novel Sequential Process from N-Methoxyamides and Vinyl Grignard Reagents:  New Synthesis of β-Aminoketones

A. Gomtsyan, R. J. Koenig, C.-H. Lee, J. Org. Chem., 2001, 66, 3613-3616.

Key Words

β-Amino Ketones, Michael Addition

ID: J54-Y2000