Direct Synthesis of β-Aminoketones from Amides via Novel Sequential Nucleophilic Substitution/Michael Reaction
Arthur Gomtsyan*
*Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, Illinois 60064
A. Gomtsyan, Org. Lett., 2000, 2, 11-13.
DOI: 10.1021/ol9911122
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Abstract
A sequential nucleophilic substitution at the carbonyl group of amides by vinylmagnesium bromide followed by Michael reaction after quench by water provides β-aminoketones.
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A. Gomtsyan, R. J. Koenig, C.-H. Lee, J. Org. Chem., 2001, 66, 3613-3616.
Key Words
β-Amino Ketones, Michael Addition
ID: J54-Y2000