Concerted Catalytic Reactions for Conversion of Ketones or Enol Acetates to Chiral Acetates
Hyun M. Jung, Jeong H. Koh, Mahn-Joo Kim and Jaiwook Park*
*Department of Chemistry and Division of Molecular & Life Science, Pohang University of Science and Technology (POSTECH), San 31 Hyoja Dong, Pohang 790-784, Korea,
Email: pjw
postech.ac.kr
H. M. Jung, J. H. Koh, M.-J. Kim, J. Park, Org. Lett., 2000, 2, 397-399.
DOI: 10.1021/ol9914043
see article for more reactions
Abstract
The combination of lipase and a ruthenium complex catalyzes the asymmetric transformation of enol acetates or ketones to chiral acetates in high yields with high optical purities in the presence of 2,6-dimethylheptan-4-ol as a hydrogen donor and 4-chlorophenyl acetate as an acyl donor.
see article for more examples
H. M. Jung, J. H. Koh, M.-J. Kim, J. Park, Org. Lett., 2000, 2, 2487-2490.
Key Words
reduction of carbonyl compounds, asymmetric acylation
ID: J54-Y2000
