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A Novel and Efficient Synthesis of 3-Fluorooxindoles from Indoles Mediated by Selectfluor

Yoshio Takeuchi*, Takanao Tarui and Norio Shibata

*Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Sugitani 2630, Toyama, 930-0194 Japan

Y. Takeuchi, T. Tarui, N. Shibata, Org. Lett., 2000, 2, 639-642.

DOI: 10.1021/ol991400y

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Treatment of several 3-substituted indoles, including derivatives of tryptophan and serotonin, with Selectfluor in acetonitrile/water provides 3-substiuted 3-fluorooxindoles in very good yields.

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Key Words

Oxindoles, Selectfluor

ID: J54-Y2000