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A Simple One-Pot Procedure for the Direct Conversion of Alcohols to Azides via Phosphate Activation

Chengzhi Yu, Bin Liu and Longqin Hu*

*Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, United States, Email:

C. Yu, B. Liu, L. Hu, Org. Lett., 2000, 2, 1959-1961.

DOI: 10.1021/ol0060376 (free Supporting Information)


Bis(2,4-dichlorophenyl) phosphate mediates an efficient one-pot preparation of alkyl azides from alkanols in the presence of 4-(dimethylamino)pyridine as a base. Phosphorylpyridinium azide is believed to be the activating agent under these conditions.

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Key Words

benzyl azides, alkyl azides

ID: J54-Y2000