A Simple One-Pot Procedure for the Direct Conversion of Alcohols to Azides via Phosphate Activation
Chengzhi Yu, Bin Liu and Longqin Hu*
*Rutgers University, Ernest Mario School of Pharmacy, 160 Frelinghuysen Road, Piscataway, NJ 08854, United States, Email: longhupharmacy.rutgers.edu
C. Yu, B. Liu, L. Hu, Org. Lett., 2000, 2, 1959-1961.
DOI: 10.1021/ol0060376 (free Supporting Information)
Bis(2,4-dichlorophenyl) phosphate mediates an efficient one-pot preparation of alkyl azides from alkanols in the presence of 4-(dimethylamino)pyridine as a base. Phosphorylpyridinium azide is believed to be the activating agent under these conditions.
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