Practical Ruthenium/Lipase-Catalyzed Asymmetric Transformations of Ketones and Enol Acetates to Chiral Acetates
Hyun M. Jung, Jeong H. Koh, Mahn-Joo Kim and Jaiwook Park
*Department of Chemistry and Division of Molecular & Life
Science, Pohang University of Science and Technology (POSTECH), San 31 Hyoja Dong, Pohang 790-784, Korea,
Email: pjw
postech.ac.kr
H. M. Jung, J. H. Koh, M.-J. Kim, J. Park, Org. Lett., 2000, 2, 2487-2490.
DOI: 10.1021/ol006169z
see article for more reactions
Abstract
Ketones were transformed to chiral acetates by a one-pot process using a lipase and an achiral ruthenium complex under 1 atm of hydrogen gas in ethyl acetate. The same catalyst system was also effective for an asymmetric transformation of enol acetates to acetates under hydrogen without additional acyl donors.
see article for more examples
Concerted Catalytic Reactions for Conversion of Ketones or Enol Acetates to Chiral Acetates
H. M. Jung, J. H. Koh, M.-J. Kim, J. Park, Org. Lett., 2000, 2, 397-399.
Key Words
reduction of carbonyl compounds, asymmetric acylation
ID: J54-Y2000
