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Orthosilicate-Mediated Esterification of Monosubstituted Phosphinic Acids

Yves R. Dumond, Rhonda L. Baker and Jean-Luc Montchamp*

*Department of Chemistry, Box 298860, Texas Christian University, Fort Worth, Texas 76129, United States, Email:

Y. R. Dumond, R. L. Baker, J.-L. Montchamp, Org. Lett., 2000, 2, 3341-3344.

DOI: 10.1021/ol006434g

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Monosubstituted phosphinic acids can be esterified with orthosilicates in excellent yields. Whereas phosphinylidene-containing acids react selectively, disubstituted phosphinic acids and phosphonic acids remain unchanged. This method provides a convenient and general alternative to more commonly employed reactions with diazomethane or carbodiimide.

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Key Words


ID: J54-Y2000