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Synthesis of Fluoren-9-ones via Palladium-Catalyzed Cyclocarbonylation of o-Halobiaryls

Marino A. Campo and Richard C. Larock

*Department of Chemistry, Iowa State University, Ames, Iowa 50011, United States, Email:

M. A. Campo, R. C. Larock, Org. Lett., 2000, 2, 3675-3677.

DOI: 10.1021/ol006585j


A palladium-catalyzed cyclocarbonylation of o-halobiaryls enables a synthesis of various substituted fluoren-9-ones bearing either electron-donating or electron-withdrawing substituents in very high yields. This chemistry has been successfully extended to polycyclic and heterocyclic fluorenones.

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ID: J54-Y2000