A Strictly "Pair"-Selective Synthesis of Conjugated Diynes via Pd-Catalyzed Cross Coupling of 1,3-Diynylzincs: A Superior Alternative to the Cadiot-Chodkiewicz Reaction
Ei-ichi Negishi*, Mitsuhiro Hata and Caiding Xu
*Herbert C. Brown Laboratories, Purdue University, West Lafayette, Indiana 47907
E.-i. Negishi, M. Hata, C. Xu, Org. Lett., 2000, 2, 3687-3689.
DOI: 10.1021/ol000270m
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Abstract
A Pd-catalyzed cross coupling of 1,3-diynylzinc compounds enables a convenient synthesis of conjugated diynes. The 1,3-diynylzincs can easily be generated in two reactions from terminal alkynes and (E)-1-iodo-2-chloroethene.
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Key Words
ID: J54-Y2000
