Organic Chemistry Portal



A Novel Synthesis of 4H-Chromen-4-ones via Intramolecular Wittig Reaction

Pradeep Kumar and Mandar S. Bodas

*Division of Organic Chemistry: Technology, National Chemical Laboratory, Pune 411008, India, Email:

P. Kumar, M. S. Bodas, Org. Lett., 2000, 2, 3821-3823.

DOI: 10.1021/ol006518p


The reaction of the silyl ester of O-acyl(aroyl)salicylic acids and (trimethylsilyl)methylenetriphenylphosphorane provides acylphosphoranes, which undergo intramolecular Wittig cyclization on the ester carbonyl to afford 4H-chromen-4-ones in very good yields.

see article for more examples

Key Words

Chromones, Wittig reaction

ID: J54-Y2000