Pd-Catalyzed Cross-Coupling Reaction of Alkyl Tosylates and Bromides with Grignard Reagents in the Presence of 1,3-Butadiene

Jun Terao, Yoshitaka Naitoh, Hitoshi Kuniyasu, Nobuaki Kambe*

*Department of Molecular Chemistry, Graduate School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka, Email: kambechem.eng.osaka-u.ac.jp

J. Terao, Y. Naitoh, H. Kuniyasu, N. Kambe, Chem. Lett., 2003, 890-891.

DOI: 10.1246/cl.2003.890

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Abstract

Pd(acac)₂ catalyzes a cross-coupling reaction of alkyl tosylates and bromides with Grignard reagents in the presence of 1,3-butadiene in good yields. This reaction proceeds efficiently at room temperature using primary and secondary alkyl and aryl Grignard reagents.

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Co-Catalyzed Cross-Coupling of Alkyl Halides with Tertiary Alkyl Grignard Reagents Using a 1,3-Butadiene Additive

T. Iwasaki, H. Takagawa, S. P. Singh, H. Kuniyasu, N. Kambe, J. Am. Chem. Soc., 2013, 135, 9604-9607.

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Key Words

alkanes

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ID: JXX-Y2003