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Tetrabutylammonium Tribromide (TBATB)-MeOH:  An Efficient Chemoselective Reagent for the Cleavage of tert-Butyldimethylsilyl (TBDMS) Ethers

Rangam Gopinath and Bhisma K. Patel*

*Department of Chemistry, Indian Institute of Technology, Guwahati-781 031, India, Email:

R. Gopinath, B. K. Patel, Org. Lett., 2000, 2, 4177-4180.

DOI: 10.1021/ol006720s

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TBDMS ethers can be cleaved selectively in the presence of isopropylidine, Bn, Ac, Bz, THP, and TBDPS groups using tetrabutylammonium tribromide in methanol. This method is high yielding, fast, clean, safe, and cost-effective.

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Key Words

TBDMS ethers

ID: J54-Y2000