Organic Chemistry Portal

Abstracts

Search:

Tetrabutylammonium Tribromide (TBATB)-MeOH:  An Efficient Chemoselective Reagent for the Cleavage of tert-Butyldimethylsilyl (TBDMS) Ethers

Rangam Gopinath and Bhisma K. Patel*

*Department of Chemistry, Indian Institute of Technology, Guwahati-781 031, India, Email: pateliitg.ernet.in

R. Gopinath, B. K. Patel, Org. Lett., 2000, 2, 4177-4180.

DOI: 10.1021/ol006720s


see article for more reactions

Abstract

TBDMS ethers can be cleaved selectively in the presence of isopropylidine, Bn, Ac, Bz, THP, and TBDPS groups using tetrabutylammonium tribromide in methanol. This method is high yielding, fast, clean, safe, and cost-effective.

see article for more examples



Key Words

TBDMS ethers


ID: J54-Y2000