Rhodium Complex-Catalyzed Reaction of Isonitriles with Carbonyl Compounds: Catalytic Synthesis of Pyrroles
Hikaru Takaya, Sachiko Kojima and Shun-Ichi Murahashi*
*Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan
H. Takaya, S. Kojima, S.-I. Murahashi, Org. Lett., 2001, 3, 421-424.
DOI: 10.1021/ol0069296
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Abstract
Low-valent rhodium complexes efficiently catalyze an activation of α-C-H bond of isonitriles. An addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding α,β-unsaturated formamides. An in situ cyclocondensation with 1,3-dicarbonyl compounds provides pyrroles.
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Key Words
ID: J54-Y2001