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A Simple Preparation of Ketones. N-Protected α-Amino Ketones from α-Amino Acids

Lidia De Luca, Giampaolo Giacomelli and Andrea Porcheddu

*Dipartimento di Chimica, Universita degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy

L. De Luca, G. Giacomelli, A. Porcheddu, Org. Lett., 2001, 3, 1435-1437.

DOI: 10.1021/ol015840c (free Supporting Information)



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Abstract

In situ generated activated esters of carboxylic acids and amino acids react with Grignard reagents and CuI to give the corresponding ketones in nearly quantitative yields. The compounds were recovered substantially pure from the reaction mixtures.

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An Easy and Convenient Synthesis of Weinreb Amides and Hydroxamates

L. De Luca, G. Giacomelli, M. Taddei, J. Org. Chem., 2001, 66, 2534-2537.


Key Words

ketones


ID: J54-Y2001