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Regioselective Palladium-Catalyzed Arylation of 2-Furaldehyde

Michael S. McClure, Bobby Glover, Ellen McSorley, Alan Millar, Martin H. Osterhout and Frank Roschangar

*GlaxoSmithKline, Chemical Development, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina 27709

M. S. McClure, B. Glover, E. McSorley, A. Millar, M. H. Osterhout, F. Roschangar, Org. Lett., 2001, 3, 1677-1680.

DOI: 10.1021/ol0158866 (free Supporting Information)

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An efficient palladium-catalyzed direct arylation of 2-furaldehyde with aryl halides provides a range of 5-aryl-2-formylfuran derivatives in good yields under mild conditions.

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Key Words

furans, heterobiaryls

ID: J54-Y2001