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Direct Reductive Amination of Aldehydes and Ketones Using Phenylsilane:  Catalysis by Dibutyltin Dichloride

Richard Apodaca* and Wei Xiao

*The R.W. Johnson Pharmaceutical Research Institute, San Diego, California 92121

R. Apodaca, W. Xiao, Org. Lett., 2001, 3, 1745-1748.

DOI: 10.1021/ol015948s

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Dibutyltin dichloride catalyzes a direct reductive amination of aldehydes and ketones in the presence of phenylsilane as a stoichiometric reductant. Suitable amines included anilines and dialkylamines but not monoalkylamines.

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Key Words

reductive amination, phenylsilane, anilines

ID: J54-Y2001