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Palladium-Catalyzed Cross-Coupling Reaction of Organoindiums with Aryl Halides in Aqueous Media

Kazuaki Takami, Hideki Yorimitsu, Hiroshi Shinokubo, Seijiro Matsubara and Koichiro Oshima*

*Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan

K. Takami, H. Yorimitsu, H. Shinokubo, S. Matsubara, K. Oshima, Org. Lett., 2001, 3, 1997-1999.

DOI: 10.1021/ol015975i

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Diaryl-, divinyl-, and dialkylindium compounds undergo a palladium-catalyzed cross-coupling reaction with aryl halides in aqueous THF to provide the corresponding coupling product in excellent yield. A wide range of functional groups are tolerated. The indium compounds can be generated from indium trichloride and two equimolar amounts of a Grignard reagent.

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Key Words

biaryl synthesis, alkenylation

ID: J54-Y2001