Catalytic Meerwein-Pondorf-Verley Reduction by Simple Aluminum Complexes

E. Joseph Campbell, Hongying Zhou and SonBinh T. Nguyen

*Department of Chemistry, Northwestern University 2145 Sheridan Road, Evanston, Illinois 60208-3113, Email: stnnorthwestern.edu

E. J. Campbell, H. Zhou, S. T. Nguyen, Org. Lett., 2001, 3, 2391-2393.

DOI: 10.1021/ol0162116

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Abstract

Catalytic MPV reduction was successfully carried out using iPrOH as the reducing agent and simple alkylaluminum reagents as precatalysts, that were converted to highly active low-aggregation aluminum alkoxides. When chiral hydride sources were utilized in the reduction of 2-chloroacetophenone, high enantioselectivity was observed.

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Key Words

Meerwein-Pondorf-Verley Reduction, isopropanol

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ID: J54-Y2001