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Highly Satisfactory Procedures for the Pd-Catalyzed Cross Coupling of Aryl Electrophiles with in Situ Generated Alkynylzinc Derivatives

Luigi Anastasia and Ei-ichi Negishi

*Herbert C. Brown Laboratories of Chemistry, Purdue University, West Lafayette, Indiana 47907

L. Anastasia, E.-i. Negishi, Org. Lett., 2001, 3, 3111-3113.

DOI: 10.1021/ol010145q


In situ conversion of terminal alkynes into alkynylzinc derivatives enables an efficient Pd-catalyzed cross coupling with aryl electrophiles. One procedure is particularly valuable in cases where electron-deficient alkynes are used, whereas the other is operationally simple and very satisfactory in less demanding cases.

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Key Words

Neghishi coupling, alkynylation of arenes

ID: J54-Y2001