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Lipase/Palladium-Catalyzed Asymmetric Transformations of Ketoximes to Optically Active Amines

Yoon Kyung Choi, Mi Jung Kim, Yangsoo Ahn and Mahn-Joo Kim

*Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea

Y. K. Choi, M. J. Kim, Y. Ahn, M.-J. Kim, Org. Lett., 2001, 3, 4099-4101.

DOI: 10.1021/ol0168622

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The combination of lipase/palladium catalysis reduces prochiral ketoximes to optically active acetylated amines in the presence of an acyl donor under 1 atm of hydrogen.

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Key Words

reduction of oximes, hydrogen

ID: J54-Y2001