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Nucleophilic Trifluoromethylation Using Trifluoromethyl Iodide. A New and Simple Alternative for the Trifluoromethylation of Aldehydes and Ketones

Samia Aït-Mohand, Naoto Takechi, Maurice Médebielle and William R. Dolbier*

*Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200

S. Aït-Mohand, N. Takechi, M. Médebielle, W. R. Dolbier, Org. Lett., 2001, 3, 4271-4273.

DOI: 10.1021/ol016933x

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A photoinduced reduction of trifluoromethyl iodide by tetrakis(dimethylamino)ethylene (TDAE) enables a nucleophilic trifluoromethylation of aldehydes and ketones.

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Key Words

trifluoromethylation, tetrakis(dimethylamino)ethylene

ID: J54-Y2001