A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates
Brian R. Linton, Andrew J. Carr, Brendan P. Orner and Andrew D. Hamilton*
*Sterling Chemistry Laboratory, Box 208107, Yale University, New Haven, Connecticut 06520,
Email: andrew.hamilton
nyu.edu
B. R. Linton, A. J. Carr, B. P. Orner, A. D. Hamilton, J. Org. Chem., 2000, 65, 1566-1568.
DOI: 10.1021/jo991458q
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Abstract
Carbamoyl isothiocyanates are ideal starting materials for the synthesis of multisubstituted guanidines. The nature of these carbamoyl thioureas permits creation of disubstituted and trisubstituted guanidines, as well as aromatic guanidines.
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Key Words
ID: J42-Y2000
