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A Versatile One-Pot Synthesis of 1,3-Substituted Guanidines from Carbamoyl Isothiocyanates

Brian R. Linton, Andrew J. Carr, Brendan P. Orner and Andrew D. Hamilton*

*Sterling Chemistry Laboratory, Box 208107, Yale University, New Haven, Connecticut 06520, Email:

B. R. Linton, A. J. Carr, B. P. Orner, A. D. Hamilton, J. Org. Chem., 2000, 65, 1566-1568.

DOI: 10.1021/jo991458q

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Carbamoyl isothiocyanates are ideal starting materials for the synthesis of multisubstituted guanidines. The nature of these carbamoyl thioureas permits creation of disubstituted and trisubstituted guanidines, as well as aromatic guanidines.

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Key Words

thioureas, guanidines

ID: J42-Y2000