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A Direct Retro-Barbier Fragmentation

Wen-Chun Zhang and Chao-Jun Li

*Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, Email:

W.-C. Zhang, C.-J. Li, J. Org. Chem., 2000, 65, 5831-5833.

DOI: 10.1021/jo000129r


A direct retro-Barbier fragmentation of cyclic tertiary alcohols proceeds under mild conditions in the presence of bromine and potassium carbonate in chloroform to provide bromoketones in high yields.

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Key Words

Ketones, Alkyl Bromides, Oxidation of Alcohols

ID: J42-Y2000