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Highly Efficient Selective Monohydrolysis of Symmetric Diesters

Satomi Niwayama*

*Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078-3071, Email: niwayamammm.muroran-it.ac.jp

S. Niwayama, J. Org. Chem., 2000, 65, 5834-5836.

DOI: 10.1021/jo0001986


Abstract

A highly efficient semi-two-phase reaction using THF-aqueous NaOH at 0C provides half-esters from symmetric diesters in high yields. Diesters that afforded the corresponding half-esters in quantitative yields all possess two carboalkoxy groups in "cis" or "geminal" orientation.

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Key Words

hydrolysis of esters


ID: J42-Y2000