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Indium(III) Chloride-Catalyzed One-Pot Synthesis of Dihydropyrimidinones by a Three-Component Coupling of 1,3-Dicarbonyl Compounds, Aldehydes, and Urea: An Improved Procedure for the Biginelli Reaction

Brindaban C. Ranu, Alakananda Hajra and Umasish Jana

*Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Calcutta 700 032, India, Email: ocbcriacs.res.in

B. C. Ranu, A. Hajra, U. Jana, J. Org. Chem., 2000, 65, 6270-6272.

DOI: 10.1021/jo000711f


Abstract

An indium(III) chloride catalyzed Biginelli reaction of 1,3-dicarbonyl compounds, aldehydes, and ureas offers an easy access to a broad range of dihydropyrimidin-2(1H)-ones and thiones in very high yields. This mild reaction offers simplicity and tolerates a wide variety of substitutions.

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Key Words

Biginelli reaction, multicomponent reactions


ID: J42-Y2000