Amidine-Promoted Addition of Chloroform to Carbonyl Compounds
Varinder K. Aggarwal and Andrea Mereu
*Department of Chemistry, University of Sheffield, Sheffield
S3 7HF, U.K.,
Email: v.aggarwal
bristol.ac.uk
V. K. Aggarwal, A. Mereu, J. Org. Chem., 2000, 65, 7211-7212.
DOI: 10.1021/jo000584n
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Abstract
Trichlorocarbinols are useful intermediates. They are usually prepared by base-promoted addition of chloroform to carbonyl compounds in the presence of strong bases, which requires low temperatures to minimize the extent of the Cannizzaro reaction. DBU promotes this addition in the absence of solvent at room temperature. Washing with water removes the amidine and gives product in high yields.
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Key Words
ID: J42-Y2000
