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Mild and Highly Efficient Method for the Silylation of Alcohols Using Hexamethyldisilazane Catalyzed by Iodine under Nearly Neutral Reaction Conditions

Babak Karimi and Behzad Golshani

*Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), P.O.Box 45195-159, Gava Zang, Zanjan, Iran, Email: karimiiasbs.ac.ir

B. Karimi, B. Golshani, J. Org. Chem., 2000, 65, 7228-7230.

DOI: 10.1021/jo005519s


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Abstract

Iodine is an efficient and practically neutral catalyst for trimethylsilylation of a variety of alcohols with 1,1,1,3,3,3-Hexamethyldisilazane (HMDS).


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proposed mechanism



Key Words

silylation


ID: J42-Y2000