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Fast Microwave-Assisted Preparation of Aryl and Vinyl Nitriles and the Corresponding Tetrazoles from Organo-halides

Mathias Alterman and Anders Hallberg*

*Department of Organic Pharmaceutical Chemistry, Uppsala Biomedical Center, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden

M. Alterman, A. Hallberg, J. Org. Chem., 2000, 65, 7984-7989.

DOI: 10.1021/jo0009954

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Aryl and vinyl nitriles have been prepared in very high yields from the corresponding bromides using palladium-catalyzed reactions under microwave irradiation. Furthermore, flash heating was used successfully for the conversion of these nitriles into aryl and vinyl tetrazoles by cycloaddition reactions. One-pot transformation of aryl halides directly to the aryl tetrazoles could also be accomplished.

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Key Words

microwave synthesis, nitriles, tetrazoles

ID: J42-Y2000