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N-Acylbenzotriazoles:  Neutral Acylating Reagents for the Preparation of Primary, Secondary, and Tertiary Amides

Alan R. Katritzky*, Hai-Ying He and Kazuyuki Suzuki

*Center for Heterocyclic Chemistry, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200

A. R. Katritzky, H.-Y. He, K. Suzuki, J. Org. Chem., 2000, 65, 8210-8213.

DOI: 10.1021/jo000792f

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Readily available N-acylbenzotriazoles efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in very good yields.

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Efficient Conversion of Carboxylic Acids into N-Acylbenzotriazoles

A. R. Katritzky, N. Kirichenko, B. V. Rogovoy, Synthesis, 2003, 2777-2780.

Efficient Microwave Access to Polysubstituted Amidines from Imidoylbenzotriazoles

A. R. Katritzky, C. Cai, S. K. Singh, J. Org. Chem., 2006, 71, 3375-3380.

Key Words

amidation, acylation

ID: J42-Y2000