Use of the Ramberg-Bäcklund Rearrangement for the Synthesis of Medium and Large Heterocyclic Alkenes:  Stereoselective Olefin Formation

David I. MaGee and Ellen J. Beck

*Department of Chemistry, University of New Brunswick, Fredericton, New Brunswick, Canada, E3B 6E2, Email: dmageeunb.ca

D. I. MaGee, E. J. Beck, J. Org. Chem., 2000, 65, 8367-8371.

DOI: 10.1021/jo000407m

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Abstract

The use of KOtBu in the Ramberg-Bäcklund rearrangement has been shown to be useful in introducing double bonds stereoselectively into azamacrocyclic systems.

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Key Words

Ramberg-Bäcklund Reaction, N-Heterocycles, cyclic amines

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ID: J42-Y2000