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A Simple Chemoselective Method for the Deprotection of Acetals and Ketals Using Bismuth Nitrate Pentahydrate

Kyle J. Eash, Michael S. Pulia, Laura C. Wieland and Ram S. Mohan

*Department of Chemistry, Illinois Wesleyan University, Bloomington, Illinois 61701, United States, Email:

K. J. Eash, M. S. Pulia, L. C. Wieland, R. S. Mohan, J. Org. Chem., 2000, 65, 8399-8341.

DOI: 10.1021/jo001202g

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The use of bismuth nitrate enables a chemoselective deprotection of acetals derived from ketones and conjugated aldehydes. The advantages of this method are the ease of work up, the observed selectivity and the use of a relatively nontoxic reagent that is easy to handle and is inexpensive.

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Key Words

dimethyl acetals

ID: J42-Y2000