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An Efficient Ketone-Catalyzed Epoxidation Using Hydrogen Peroxide as Oxidant

Lianhe Shu and Yian Shi

*Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, Email: yian.shicolostate.edu

L. Shu, Y. Shi, J. Org. Chem., 2000, 65, 8807-8810.

DOI: 10.1021/jo001180y (free Supporting Information)


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Abstract

Trifluoroacetone catalyzes a mild and operationally simple epoxidation of various alkens in good yields using hydrogen peroxide as primary oxidant at high pH. The use of H2O2 as oxidant significantly reduces the amount of solvent and salts introduced.

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Key Words

hydrogen peroxide, epoxides, organocatalysis


ID: J42-Y2000