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Application of NAD(P)H Model Hantzsch 1,4-Dihydropyridine as a Mild Reducing Agent in Preparation of Cyclo Compounds

Xiao-Qing Zhu*, Hong-Yi Wang, Jian-Shuang Wang and You-Cheng Liu

*Department of Chemistry, National Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China, Email:

X.-Q. Zhu, H.-Y. Wang, J.-S. Wang, Y.-C. Liu, J. Org. Chem., 2001, 66, 344-347.

DOI: 10.1021/jo001362s

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NAD(P)H mimic reactions with Hantzsch 1,4-dihydropyridine provide three-, five- and seven-membered ring compounds. The method offers readily available starting materials, very high yields, mild conditions, and simple workup.

proposed mechanism

Key Words

Hantzsch Ester, Cyclopropanes

ID: J42-Y2001