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Acylation and Related Reactions under Microwaves. 4. Sulfonylation Reactions of Aromatics

Julien Marquié, André Laporterie, Jacques Dubac*, Nicolas Roques and Jean-Roger Desmurs

*Hétérochimie Fondamentale et Appliquée (UMR 5069 CNRS), Université Paul-Sabatier, 118 route de Narbonne, 31062 Toulouse Cédex, France

J. Marquié, A. Laporterie, J. Dubac, N. Roques, J.-R. Desmurs, J. Org. Chem., 2001, 66, 421-425.

DOI: 10.1021/jo001362s

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FeCl3 catalyzes a solvent-free sulfonylation of arenes under microwave irradiation. With more reactive and/or nonvolatile substrates (anisole, xylenes, mesitylene) a short reaction time at constant MW power without control of the temperature was used. With less reactive and/or low-boiling reagents (benzene, toluene, halobenzenes), the MW power was controlled. A nonthermal effect was not observed.

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Key Words

Friedel-Crafts Acylation, Sulfonylation, Microwave Synthesis

ID: J42-Y2001