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Oxidative Cleavage of 1,3-Dicarbonyls to Carboxylic Acids with Oxone

Scott W. Ashford* and Kevin C. Grega

*Chemical Process Research and Development, 1500-91-201, Pharmacia, Kalamazoo, Michigan 49001, USA, Email:

S. W. Ashford, K. C. Grega, J. Org. Chem., 2001, 66, 1523-1524.

DOI: 10.1021/jo001579m

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Oxone oxidatively degrades 1,3-dicarbonyl compounds and α-hydroxy ketones to carboxylic acids. This method compliments existing methodologies and is in general a milder alternative to the haloform reaction.

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Key Words

carboxylic acids, oxone

ID: J42-Y2001