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Suzuki Reaction of Vinyl Triflates from Six- and Seven-Membered N-Alkoxycarbonyl Lactams with Boronic Acids and Esters

Ernesto G. Occhiato*, Andrea Trabocchi and Antonio Guarna

*Department of Chemistry "U. Schiff", via della Lastruccia 3-13, 50019 Sesto Fiorentino (FI), Italy, Email:

E. G. Occhiato, A. Trabocchi, A. Guarna, J. Org. Chem., 2001, 66, 2459-2465.

DOI: 10.1021/jo001807c

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Suzuki coupling reactions of alkenylboronates and arylboronic acids with six- and seven-membered lactam-derived N-alkoxycarbonyl vinyl triflates provide the corresponding 6- or 7-substituted N-alkoxycarbonyl-3,4-dihydro-2H-pyridines and N-alkoxycarbonyl-2,3,4,5-tetrahydroazepines in high yields under very mild conditions.

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Key Words

1,2,3,4-Tetrahydropyridines, Suzuki Coupling

ID: J42-Y2001