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Practical Cobalt Carbonyl Catalysis in the Thermal Pauson-Khand Reaction:  Efficiency Enhancement Using Lewis Bases

Marie E. Krafft, Llorente V. R. Boņaga and Chitaru Hirosawa

*Department of Chemistry, The Florida State University, Tallahassee, Florida 32306-4390

M. E. Krafft, L. V. R. Boņaga, C. Hirosawa, J. Org. Chem., 2001, 66, 3004-3020.

DOI: 10.1021/jo0057708

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Commercially available Co2(CO)8 and Co4(CO)12, and enyne-Co2(CO)6 complexes are sufficiently effective in catalyzing the Pauson-Khand reaction under one atmosphere of CO pressure. The efficiencies of these cyclization protocols could be enhanced by the presence of cyclohexylamine.

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Key Words

Pauson-Khand Reaction, cyclopentenones

ID: J42-Y2001