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Oxidation of Benzyl Chlorides and Bromides to Benzoic Acids with 30% Hydrogen Peroxide in the Presence of Na2WO4, Na2VO4, or Na2MoO4 under Organic Solvent-Free Conditions

Min Shi* and Yan-Shu Feng

*Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, Email:

M. Shi, Y.-S. Feng, J. Org. Chem., 2001, 66, 3235-3237.

DOI: 10.1021/jo001796n


Benzyl chlorides and bromides can be directly oxidized to the corresponding benzoic acids in an eco-safer way using 30% hydrogen peroxide with Na2WO4 * 2H2O as a catalyst and [CH3(n-C8H17)3N]+HSO4 as a phase-transfer agent (PTC) without any organic solvents.

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Key Words

carboxylic acids, hydrogen peroxide

ID: J42-Y2001