Improved Catalysts for the Palladium-Catalyzed Synthesis of Oxindoles by Amide α-Arylation. Rate Acceleration, Use of Aryl Chloride Substrates, and a New Carbene Ligand for Asymmetric Transformations
Sunwoo Lee and John F. Hartwig*
*Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06520-8107, Email: jhartwigberkeley.edu
S. Lee, J. F. Hartwig, J. Org. Chem., 2001, 66, 3402-3415.
DOI: 10.1021/jo005761z
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Abstract
Catalysts comprised of Pd(OAc)2 and either PCy3 or sterically hindered N-heterocyclic carbene ligands provide fast rates for a mild, palladium-catalyzed synthesis of oxindoles in high yields by amide α-arylation.
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Key Words
ID: J42-Y2001