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Dynamic Kinetic Resolution of β-Azido Alcohols. An Efficient Route to Chiral Aziridines and β-Amino Alcohols

Oscar Pāmies and Jan-E. Bäckvall

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-10691 Stockholm, Sweden, Email:

O. Pāmies, J.-E. Bäckvall, J. Org. Chem., 2001, 66, 4022-4025.

DOI: 10.1021/jo015579d

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Lipase-catalyzed enantioselective esterification of β-azido alcohols in combination with ruthenium-catalyzed alcohol isomerization enables a successful dynamic kinetic resolution (DKR) of racemic β-azido alcohols to the corresponding enantiomerically pure acetates.

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Key Words

β-azido alcohols, acylation

ID: J42-Y2001