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Rapid Homogeneous-Phase Sonogashira Coupling Reactions Using Controlled Microwave Heating

Máté Erdélyi and Adolf Gogoll

*Department of Chemistry-BMC, Uppsala University, Uppsala SE-751 23, Sweden, Email:

M. Erdélyi, A. Gogoll, J. Org. Chem., 2001, 66, 4165-4169.

DOI: 10.1021/jo0057250

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A microwave-enhanced, rapid and efficient homogeneous-phase version of the Sonogashira reaction has been applied to the coupling of a broad range of aryl iodides, bromides, triflates, and aryl chloride, as well as pyridine and thiophene derivatives with trimethylsilylacetylene in excellent yields in 5-25 min.

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Key Words

Sonogashira coupling, alkynylation, microwave synthesis

ID: J42-Y2001