Iridium-Catalyzed Transfer Hydrogenation of α,β-Unsaturated and Saturated Carbonyl Compounds with 2-Propanol

Satoshi Sakaguchi, Takumi Yamaga and Yasutaka Ishii*

*Department of Applied Chemistry, Faculty of Engineering & High Technology Research Center, Kansai University, Suita, Osaka 564-8680, Japan

S. Sakaguchi, T. Yamaga, Y. Ishii, J. Org. Chem., 2001, 66, 4710-4712.

DOI: 10.1021/jo0156722

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Abstract

A selective transfer hydrogenation of α,β-unsaturated carbonyl compounds to saturated ones in very good yields was achieved by the use of 2-propanol as a hydrogen donor under the influence of catalytic amounts of [Ir(cod)Cl]₂, 1,3-bis(diphenylphosphino)propane (dppp), and Cs₂CO₃. The reduction of carbonyl compounds to alcohols can also promoted by the same catalytic system.

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Key Words

1,4-reduction, 2-propanol

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ID: J42-Y2001