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A Mild Procedure for the Reduction of Pyridine N-Oxides to Piperidines Using Ammonium Formate

Boulos Zacharie, Nancie Moreau and Christopher Dockendorff

*BioChem Pharma Inc., 275 Armand-Frappier Boulevard, Laval, Quebec, Canada H7V 4A7, Email:

B. Zacharie, N. Moreau, C. Dockendorff, J. Org. Chem., 2001, 66, 5264-5265.

DOI: 10.1021/jo015649g


The use of ammonium formate and palladium on carbon enables an efficient reduction of pyridine N-oxides to piperidines. The advantages of this procedure are simplicity of the reaction, high yield, mild conditions, and the avoidance of strong acid and harsh reagents.

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Key Words

piperidines, formic acid

ID: J42-Y2001