A Mild Procedure for the Reduction of Pyridine N-Oxides to Piperidines Using Ammonium Formate
Boulos Zacharie, Nancie Moreau and Christopher Dockendorff
*BioChem Pharma Inc., 275 Armand-Frappier Boulevard, Laval,
Quebec, Canada H7V 4A7,
Email: b.zacharie
prometic.com
B. Zacharie, N. Moreau, C. Dockendorff, J. Org. Chem., 2001, 66, 5264-5265.
DOI: 10.1021/jo015649g
Abstract
The use of ammonium formate and palladium on carbon enables an efficient reduction of pyridine N-oxides to piperidines. The advantages of this procedure are simplicity of the reaction, high yield, mild conditions, and the avoidance of strong acid and harsh reagents.
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Key Words
ID: J42-Y2001
