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Efficient Baylis-Hillman Reaction Using Stoichiometric Base Catalyst and an Aqueous Medium

Chengzhi Yu, Bin Liu and Longqin Hu*

*Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, the State University of New Jersey, 08854-8020, United States, Email:

C. Yu, B. Liu, L. Hu, J. Org. Chem., 2001, 66, 5413-5418.

DOI: 10.1021/jo015628m


The use of a stoichiometric amount of 1,4-diazabicyclo[2,2,2]octane (DABCO) and an aqueous medium proved to be successful in converting a variety of aliphatic and aromatic aldehydes to their corresponding Baylis-Hillman products in high yield and short reaction time.

see article for more examples

proposed mechanism

Succesful Baylis Hillman Reaction of Acrylamide with Aromatic Aldehydes

C. Yu, L. Hu, J. Org. Chem., 2002, 67, 219-223.

Key Words

Baylis-Hillman reaction

ID: J42-Y2001