Efficient Baylis-Hillman Reaction Using Stoichiometric Base Catalyst and an Aqueous Medium
Chengzhi Yu, Bin Liu and Longqin Hu*
*Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, the
State University of New Jersey, 08854-8020, United States,
Email: longhu
pharmacy.rutgers.edu
C. Yu, B. Liu, L. Hu, J. Org. Chem., 2001, 66, 5413-5418.
DOI: 10.1021/jo015628m
Abstract
The use of a stoichiometric amount of 1,4-diazabicyclo[2,2,2]octane (DABCO) and an aqueous medium proved to be successful in converting a variety of aliphatic and aromatic aldehydes to their corresponding Baylis-Hillman products in high yield and short reaction time.
see article for more examples
proposed mechanism
Succesful Baylis Hillman Reaction of Acrylamide with Aromatic Aldehydes
C. Yu, L. Hu, J. Org. Chem., 2002, 67, 219-223.
Key Words
ID: J42-Y2001
