Efficient Baylis-Hillman Reaction Using Stoichiometric Base Catalyst and an Aqueous Medium
Chengzhi Yu, Bin Liu and Longqin Hu*
*Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, the State University of New Jersey, 08854-8020, United States, Email: longhupharmacy.rutgers.edu
C. Yu, B. Liu, L. Hu, J. Org. Chem., 2001, 66, 5413-5418.
The use of a stoichiometric amount of 1,4-diazabicyclo[2,2,2]octane (DABCO) and an aqueous medium proved to be successful in converting a variety of aliphatic and aromatic aldehydes to their corresponding Baylis-Hillman products in high yield and short reaction time.
see article for more examples
C. Yu, L. Hu, J. Org. Chem., 2002, 67, 219-223.