Organic Chemistry Portal

Abstracts

Search:

A New and Direct Synthesis of 2-Substituted Pyrrolidines

Miguel Yus*, Tatiana Soler and Francisco Foubelo*

*Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain, Email: yusua.es, foubeloua.es

M. Yus, T. Soler, F. Foubelo, J. Org. Chem., 2001, 66, 6207-6208.

DOI: 10.1021/jo010419n


see article for more reactions

Abstract

2-substituted pyrrolidines, including nornicotine, can be prepared from very simple materials, such as carbonyl compounds (mainly aromatic aldehydes) and 3-chloropropylamine. In the case of imines derived from aliphatic ketones and aldehydes, this methodology gives significantly lower yields.

see article for more examples



Key Words

pyrrolidines, lithium


ID: J42-Y2001