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A New and Direct Synthesis of 2-Substituted Pyrrolidines

Miguel Yus*, Tatiana Soler and Francisco Foubelo*

*Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain, Email:,

M. Yus, T. Soler, F. Foubelo, J. Org. Chem., 2001, 66, 6207-6208.

DOI: 10.1021/jo010419n

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2-substituted pyrrolidines, including nornicotine, can be prepared from very simple materials, such as carbonyl compounds (mainly aromatic aldehydes) and 3-chloropropylamine. In the case of imines derived from aliphatic ketones and aldehydes, this methodology gives significantly lower yields.

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Key Words

pyrrolidines, lithium

ID: J42-Y2001