Microbial Deracemization of 1-Aryl and 1-Heteroaryl Secondary Alcohols
Graham R. Allan and Andrew J. Carnell
*Department of Chemistry, Robert Robinson Laboratories, University of Liverpool, Liverpool L69 7ZD, Email: A.J.Carnellliverpool.ac.uk
G. R. Allan, A. J. Carnell, J. Org. Chem., 2001, 66, 6495-6497.
see article for more reactions
Sphingomonas paucimobilis NCIMB 8195 catalyzes an efficient deracemization of a wide range of secondary alcohols leading to up to 90% yield of the (R)-alcohol. The corresponding ketones were formed at various levels during each of the biotransformations, indicating that stereoinversion of the (S)-alcohol proceeds by sequential oxidation and reduction.
see article for more examples
Alcohols, Alcohol Dehydrogenase